Journal article
Increasing the accuracy of peanut allergy diagnosis by using Ara h 2
TD Dang, M Tang, S Choo, PV Licciardi, JJ Koplin, PE Martin, T Tan, LC Gurrin, AL Ponsonby, D Tey, M Robinson, SC Dharmage, KJ Allen
Journal of Allergy and Clinical Immunology | Published : 2012
Abstract
Background: Measurement of whole peanut-specific IgE (sIgE) is often used to confirm sensitization but does not reliably predict allergy. Ara h 2 is the dominant peanut allergen detected in 90% to 100% of patients with peanut allergy and could help improve diagnosis. Objectives: We sought to determine whether Ara h 2 testing might improve the accuracy of diagnosing peanut allergy and therefore circumvent the need for an oral food challenge (OFC). Methods: Infants from the population-based HealthNuts study underwent skin prick tests to determine peanut sensitization and subsequently underwent a peanut OFC to confirm allergy status. In a stratified random sample of 200 infants (100 with peanut..
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Funding Acknowledgements
Funding for this project was obtained from the Australian National Health & Medical Research Council, the Ilhan Food Allergy Foundation, AnaphylaxiStop, and the Victorian Government's Operational Infrastructure Support Program. K.J.A. is a Viertel Senior Medical Research Fellow, J.J.K. is supported by an NHMRC Capacity Building Grant in Population Health postdoctoral fellowship, and L.C.G., A.-L.P., and S.C.D. hold National Health & Medical Research Council Awards. J.J.K., P.E.M., and T.D.D. are Australian Postgraduate Award scholars. T.T. is a recipient of a Malaysian Government Scholarship.M. Tang receives research support from Phadia. S. Choo receives research support from Abacus ALS. A.-L. Ponsonby receives research support from the National Health and Medical Research Council. K. J. Allen receives speaker's fees from Abbott, Wyeth, and Nutricia. The rest of the authors declare that they have no relevant conflicts of interest.