Journal article
Dysfunction in the fronto-parietal network in attention deficit hyperactivity disorder (ADHD): An fMRI study
TJ Silk, A Vance, N Rinehart, JL Bradshaw, R Cunnington
Brain Imaging and Behavior | SPRINGER | Published : 2008
Abstract
ADHD is associated with spatial working memory deficits, thought to be subserved by dysfunction of neural circuits. In this study we aimed to further examine fronto-parietal dysfunction in ADHD by examining brain activation associated with the Raven's Progressive Matrices task, a visuo-spatial pattern sequencing task involving relational reasoning and thereby placing high-demand loading on the prefrontal cortex. Functional MRI was conducted on twelve right-handed 8-12 year old boys with ADHD-combined type and 12 right-handed, age and performance IQ-matched, healthy boys as they completed items from the Raven's Progressive Matrices. Our findings further confirm striatum and parietal lobe dysf..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
This work was supported by the Eric Ormond Baker Trust, the National Health and Medical Research Council (384419), by a research project grant (2005) from the Murdoch Children's Research Institute, and the Royal Children's Hospital staff and patients. RC was supported by a Fellowship of the NHMRC (217025). TS was supported by a Fellowship of the Australian Rotary Health Research Fund, and is currently supported by the NHMRC Australian Clinical Research Fellowship.