CD46 signaling in T cells: Linking pathogens with polarity
Edwin D Hawkins, Jane Oliaro
FEBS LETTERS | ELSEVIER SCIENCE BV | Published : 2010
CD46 is a cell surface protein that regulates complement activity and is utilized as a receptor by numerous viral and bacterial pathogens that infect humans. CD46 is not just an entry site for pathogens, but can affect various cellular activities in response to pathogen binding that can have profound consequences for the host response to infection. The study of CD46 signaling in T cells has emerged as an exciting area of research that is shedding new light on how pathogens might manipulate the host immune response. This review will focus on our current understanding of CD46 signaling in T cell polarity and how this might influence disease outcome.
We thank Dr. Sarah Russell and Dr. Ilia Voskoboinik for critical reading of the manuscript and the National Health and Medical Research Council of Australia for funding support. We apologise for the many references that were not cited due to space limitations.