Journal article
Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: A pooled analysis of 18 prospective cohort studies
X Zhang, D Spiegelman, L Baglietto, L Bernstein, DA Boggs, PA Van Den Brandt, JE Buring, SM Gapstur, GG Giles, E Giovannucci, G Goodman, SE Hankinson, KJ Helzlsouer, PL Horn-Ross, M Inoue, S Jung, P Khudyakov, SC Larsson, M Lof, ML McCullough Show all
American Journal of Clinical Nutrition | OXFORD UNIV PRESS | Published : 2012
Abstract
Background: Epidemiologic studies examining associations between carotenoid intakes and risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status are limited. Objective: We investigated these associations in a pooled analysis of 18 cohort studies. Design: Of 1,028,438 participants followed for a maximum follow-up of 26 y across studies, 33,380 incident invasive breast cancers were identified. Study-specific RRs and 95% CIs were estimated by using Cox proportional hazards regression and then pooled by using a random-effects model. Results: α-Carotene, β-carotene, and lutein/zeaxanthin intakes were inversely associated with the risk of ER-negative (ER-) breast cance..
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Awarded by National Cancer Institute
Funding Acknowledgements
Supported by NIH grant CA055075 and a Breast Cancer Research Foundation grant.