Review article: The pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract

Abstract

Background The renin-angiotensin system (RAS) is a homeostatic pathway widely known to regulate cardiovascular and renal physiology; however, little is known about its influence in gastrointestinal tissues. Aim To elicit the anatomical distribution and physiological significance of the components of the RAS in the gastrointestinal tract. Methods An extensive online literature review including Pubmed and Medline. Results There is evidence for RAS involvement in gastrointestinal physiology and pathophysiology, with all the components required for autonomous regulation identified throughout the gastrointestinal tract. The RAS is implicated in the regulation of glucose, amino acid, fluid and ele..