Method to Impart Electro- and Biofunctionality to Neural Scaffolds Using Graphene-Polyelectrolyte Multilayers
Kun Zhou, George A Thouas, Claude C Bernard, David R Nisbet, David I Finkelstein, Dan Li, John S Forsythe
ACS APPLIED MATERIALS & INTERFACES | AMER CHEMICAL SOC | Published : 2012
Electroactive scaffolds that are passively conductive and able to transmit applied electrical stimuli are of increasing importance for neural tissue engineering. Here, we report a process of rendering both 2D and 3D polymer scaffolds electrically conducting, while also enhancing neuron attachment. Graphene-heparin/poly-l-lysine polyelectrolytes were assembled via layer-by-layer (LbL) deposition onto 2D surfaces and 3D electrospun nanofibers. The employed LbL coating technique in this work enables the electro- and biofunctionalization of complex 3D scaffold structures. LbL assembly was characterized by a steady mass increase during the in situ deposition process in 2D, with regular step chang..View full abstract
Awarded by ARC Discovery
This work was supported by ARC Special Initiative in bionic vision science & technology, ARC Discovery (DP0985433), the Contributing to Australian Scholarship and Science (CASS) Foundation, the Eva and Les Erdi AUSiMED Fellowship in Neurological Diseases, the Diana Asmar Fund, and the National Health and Medical Research Council of Australia.