Journal article

Genome-Wide Transcription Responses to Synchrotron Microbeam Radiotherapy

Carl N Sprung, Yuqing Yang, Helen B Forrester, Jason Li, Marina Zaitseva, Leonie Cann, Tina Restall, Robin L Anderson, Jeffrey C Crosbie, Peter AW Rogers



The majority of cancer patients achieve benefit from radiotherapy. A significant limitation of radiotherapy is its relatively low therapeutic index, defined as the maximum radiation dose that causes acceptable normal tissue damage to the minimum dose required to achieve tumor control. Recently, a new radiotherapy modality using synchrotron-generated X-ray microbeam radiotherapy has been demonstrated in animal models to ablate tumors with concurrent sparing of normal tissue. Very little work has been undertaken into the cellular and molecular mechanisms that differentiate microbeam radiotherapy from broad beam. The purpose of this study was to investigate and compare the whole genome transcri..

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Awarded by Australian National Health and Medical Research Council

Awarded by Australian Government Department of Health and Ageing

Funding Acknowledgements

This research was supported by the Australian National Health and Medical Research Council grant no. 606614, the Australian Government Department of Health and Ageing grant no. 1002743, the Australian National Breast Cancer Foundation, the Australian Government's Access to Major Research Facilities Programs, the Cancer Council of Victoria Venture Grant Scheme and the Victorian Government's Operational Infrastructure Support Program. We are grateful to our colleagues at the Spring-8 synchrotron for facilitating our experiments, particularly Dr. Naoto Yagi. We thank Dr. Duncan Butler (ARPANSA) for technical assistance during the experiments.