Journal article

Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium

Virginie JM Verhoeven, Pirro G Hysi, Seang-Mei Saw, Veronique Vitart, Alireza Mirshahi, Jeremy A Guggenheim, Mary Frances Cotch, Kenji Yamashiro, Paul N Baird, David A Mackey, Robert Wojciechowski, M Kamran Ikram, Alex W Hewitt, Priya Duggal, Sarayut Janmahasatian, Chiea-Chuen Khor, Qiao Fan, Xin Zhou, Terri L Young, E-Shyong Tai Show all

Human Genetics | SPRINGER | Published : 2012

Grants

Awarded by Wellcome Trust


Awarded by National Institutes of Health


Awarded by National Eye Institute Intramural Research Programs


Awarded by UK Medical Research Council


Awarded by National Eye Research Centre, Bristol


Awarded by National Eye Institute


Awarded by Australian National Health and Medical Research Council (NHMRC) Enabling Grant


Awarded by National Institutes of Health/National Eye Institute


Awarded by Netherlands Scientific Organization


Awarded by Australian National Health & Medical Research Council (NH& MRC), Canberra Australia


Awarded by NH& MRC research fellowships


Awarded by Republic of Croatia Ministry of Science, Education and Sports


Awarded by European Union


Awarded by NEI


Awarded by National Heart, Lung, and Blood Institute


Awarded by Boston University


Awarded by government of Rheinland-Pfalz ("Stiftung Rheinland Pfalz fur Innovation"


Awarded by Federal Ministry of Education and Research, Germany


Awarded by Japan Society for the Promotion of Science, Tokyo


Awarded by Italian Ministry of Education, University and Research


Awarded by Netherlands Organisation of Scientific Research (NWO)


Awarded by National Medical Research Council, Singapore


Awarded by Singapore Bio-Medical Research Council


Awarded by European Community's Seventh Framework Programme


Awarded by ENGAGE project


Awarded by European Community


Awarded by ENGAGE


Awarded by US National Institutes of Health/National Eye Institute


Awarded by Academy of Finland


Awarded by Turku University Hospital Medical Funds


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Awarded by Chief Scientist Office


Funding Acknowledgements

1958 British Birth Cohort was funded by the Medical Research Council's Health of the Public grant (PIs Power and Strachan); the Wellcome Trust (083478 to J.S.R.); the National Institute for Health Research as Specialist Biomedical Research Centres partnering respectively with Great Ormond Street and Moorfields Hospitals; and the Ulverscroft Vision Research Group.AGES has been funded by National Institutes of Health (N01AG12100), the National Insitute on Aging and National Eye Institute Intramural Research Programs (ZIAAG007380, ZI-AEY000401), Hjartavernd (the Icelandic Heart Association); and the Althingi (the Icelandic Parliament). This study acknowledges the contribution of collaborators on the vision component, Tamara Harris, Lenore Launer, Melissa Garcia, Susan Corwin, Fridbert Jonasson, Johanna Eyrun Sverrisdottir, Sigurdur Sigurdsson, and the staff at Hjartavernd.Core support for ALSPAC was provided by the UK Medical Research Council (4882); the Wellcome Trust (076467); the University of Bristol; and for this research specifically by the National Eye Research Centre, Bristol (SCIAD053). The study acknowledges Cathy Williams as a guarantor for the contents of this paper.The AREDS studies were supported by contracts from National Eye Institute/National Institutes of Health, Bethesda, MD, with additional support from Bausch & Lomb Inc, Rochester, NY. The genotyping costs were supported by the National Eye Institute (R01 EY020483 to D. S.) and some of the analyses were supported by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health, USA. AREDS acknowledges Emily Chew and Frederick Ferris, National Eye Institute, National Institutes of Health, Bethesda, MD; and the Center for Inherited Disease Research, Baltimore, MD where SNP genotyping was carried out.Australian Twins was supported by an Australian National Health and Medical Research Council (NHMRC) Enabling Grant (20042009, 350415, 2005-2007); Clifford Craig Medical Research Trust; Ophthalmic Research Institute of Australia; American Health Assistance Foundation; Peggy and Leslie Cranbourne Foundation; Foundation for Children; Jack Brockhoff Foundation; National Institutes of Health/National Eye Institute (RO1EY01824601 (2007-2010)); Pfizer Australia Senior Research Fellowship (to D. A. M.); and Australian NHMRC Career Development Award (to S. M.). Genotyping was funded by an NHMRC Medical Genomics Grant and NIH Center for Inherited Disease Research as part of an National Eye Institute National Institutes of Health project grant, Australian sample imputation analyses were carried out on the Genetic Cluster Computer which is financially supported by the Netherlands Scientific Organization (NWO48005003). Australian Twins thanks Stuart Macgregor, Grant W. Montgomery, Nicholas G. Martin, Scott D. Gordon, Dale R. Nyholt, Sarah E. Medland, Brian P. McEvoy, Margaret J. Wright, Anjali K. Henders, Megan J. Campbell for ascertaining and processing genotyping data; Jane MacKinnon, Shayne Brown, Lisa Kearns, Jonathan Ruddle, Paul Sanfilippo, Sandra Staffieri, Olivia Bigault, Colleen Wilkinson, Jamie Craig, Yaling Ma, Julie Barbour for assisting with clinical examinations; and Dr Camilla Day and staff.The Blue Mountains Eye Study was supported by the Australian National Health & Medical Research Council (NH& MRC), Canberra Australia (974159, 211069, 457349, 512423, 475604, 529912); the Centre for Clinical Research Excellence in Translational Clinical Research in Eye Diseases; NH& MRC research fellowships (358702, 632909 to J. J. W, 1028444 to P. N. B.); and the Wellcome Trust, UK as part of Wellcome Trust Case Control Consortium 2 (A Viswanathan, P McGuffin, P Mitchell, F Topouzis, P Foster) for genotyping costs of the entire BMES population (085475B08Z, 08547508Z, 076113). The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian government. BMES acknowledges Elena Rochtchina from the Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute University of Sydney (NSW Australia); John Attia, Rodney Scott, Elizabeth G. Holliday from the University of Newcastle (Newcastle, NSW Australia); Jing Xie, Maria Schache and Andrea J. Richardson from the Centre for Eye Research Australia, Department of Ophthalmology, University of Melbourne; Michael Inouye, The Walter and Elisa Hall Institute of Medical Research (Victoria, Australia); Ananth Viswanathan, Moorfields Eye Hospital (London, UK); Paul J. Foster, NIHR Biomedical Research Centre for Ophthalmology, UCL Institute of Ophthalmology & Moorfields Eye Hospital (London); Peter McGuffin, MRC Social Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College (London, United Kingdom); Fotis Topouzis, Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital (Thessaloniki, Greece); Xueling Sim, National University of Singapore; members of the Wellcome Trust Case Control Consortium 2.(Membership of Wellcome Trust Case Control Consortium 2 Peter Donnelly 1,2, Ines Barroso 3, Jenefer M Blackwell 4, 5, Elvira Bramon 6, Matthew A Brown 7, Juan P Casas 8, Aiden Corvin 9, Panos Deloukas 3, Audrey Duncanson 10, Janusz Jankowski 11, Hugh S Markus 12, Christopher G Mathew 13, Colin NA Palmer 14, Robert Plomin 15, Anna Rautanen 1, Stephen J Sawcer 16, Richard C Trembath 13, Ananth C Viswanathan 17, Nicholas W Wood 18, Chris C A Spencer 1, Gavin Band 1, Ce ' line Bellenguez 1, Colin Freeman 1, Garrett Hellenthal 1, Eleni Giannoulatou 1, Matti Pirinen 1, Richard Pearson 1, Amy Strange 1, Zhan Su 1, Damjan Vukcevic 1, Cordelia Langford 3, Sarah E Hunt 3, Sarah Edkins 3, Rhian Gwilliam 3, Hannah Blackburn 3, Suzannah J Bumpstead 3, Serge Dronov 3, Matthew Gillman 3, Emma Gray 3, Naomi Hammond 3, Alagurevathi Jayakumar 3, Owen T McCann 3, Jennifer Liddle 3, Simon C Potter 3, Radhi Ravindrarajah 3, Michelle Ricketts 3, Matthew Waller 3, Paul Weston 3, Sara Widaa 3, Pamela Whittaker 3 1 Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7LJ, UK; 2 Dept Statistics, University of Oxford, Oxford OX1 3TG, UK; 3 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK; 4 Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, 100 Roberts Road, Subiaco, Western Australia 6008; 5 Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Cambridge CB2 0XY, UK; 6 Department of Psychosis Studies, NIHR Biomedical Research Centre for Mental Health at the Institute of Psychiatry, King's College London and The South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AF, UK; 7 University of Queensland Diamantina Institute, Brisbane, Queensland, Australia; 8 Dept Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT and Dept Epidemiology and Public Health, University College London WC1E 6BT, UK; 9 Neuropsychiatric Genetics Research Group, Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Eire; 10 Molecular and Physiological Sciences, The Wellcome Trust, London NW1 2BE; 11 Centre for Digestive Diseases, Queen Mary University of London, London E1 2AD, UK and Digestive Diseases Centre, Leicester Royal Infirmary, Leicester LE7 7HH, UK and Department of Clinical Pharmacology, Old Road Campus, University of Oxford, Oxford OX3 7DQ, UK; 12 Clinical Neurosciences, St George's University of London, London SW17 0RE; 13 King's College London Dept Medical and Molecular Genetics, School of Medicine, Guy's Hospital, London SE1 9RT, UK; 14 Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK; 15 King's College London Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK; 16 University of Cambridge Dept Clinical Neurosciences, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK; 17 NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London EC1 V 2PD, UK; 18 Dept Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1 N 3BG, UK.).The CROATIA studies were funded by grants from the Medical Research Council (UK) and from the Republic of Croatia Ministry of Science, Education and Sports (10810803150302); and the CROATIA- Korcula genotyping was funded by the European Union framework program 6 project EUROSPAN (LSHGCT2006018947). The CROATIA studies acknowledges Dr. Goran Bencic, Prof. Zoran Vatavuk, Biljana Andrijevic Derk, Valentina Lacmanovic Loncar, Kresimir Mandic, Antonija Mandic, Ivan S. kegro, Jasna Pavicic Astalos., Ivana Merc, Miljenka Martinovic, Petra Kralj, Tamara Knezevic and Katja Barac-Juretic as well as the recruitment team from the Croatian Centre for Global Health, University of Split and the Institute of Anthropological Research in Zagreb for the ophthalmological data collection; Peter Lichner and the Helmholtz Zentrum Munchen (Munich, Germany), AROS Applied Biotechnology, Aarhus, Denmark and the Wellcome Trust Clinical facility (Edinburgh, United Kingdom) for the SNP genotyping all studies.ORCADES was supported by the Chief Scientist Office of the Scottish Government, the Royal Society, the Medical Research Council Human Genetics Unit and the European Union framework program 6 EUROSPAN project (LSHGCT2006018947). ORCADES acknowledges the invaluable contributions of Lorraine Anderson and the research nurses in Orkney, in particular Margaret Pratt who performed the eye measurements, as well as the administrative team in Edinburgh University; and the Wellcome Trust Clinical facility (Edinburgh, United Kingdom) for DNA extraction; and Peter Lichner and the Helmholtz Zentrum Munchen (Munich, Germany) for genotyping.EGCUT received financing by FP7 grants (201413, 245536); Estonian Government (SF0180142s08); and the European Union through the European Regional Development Fund, in the frame of Centre of Excellence in Genomics and Estonian Research Infrastructure's Roadmap. EGCUT acknowledges Ms. M. Hass and Mr. V. Soo.FITSA was supported by ENGAGE (FP7-HEALTH-F4-2007, 201413); the Academy of Finland Center of Excellence in Complex Disease Genetics (213506, 129680); the Academy of Finland Ageing Programme; and the Finnish Ministry of Culture and Education and University of Jyvaskyla. For FITSA the contributions of Emmi Tikkanen, Samuli Ripatti and Jaakko Kaprio are acknowledged.Framingham Eye Study was supported by NEI (N01EY22112, N01EY92109); the National Heart, Lung, and Blood Institute (N02HL64278) for SHARe genotyping; Boston University (N01HC25195); and by intramural funds of the National Human Genome Research Institute, NIH, USA (to R. W. and J.E.B.W.) GHS was funded through the government of Rheinland-Pfalz ("Stiftung Rheinland Pfalz fur Innovation" (AZ961386261733); the research programs "Wissen schafft Zukunft" and "Schwerpunkt Vaskulare Pravention" of the Johannes Gutenberg-University of Mainz; Boehringer Ingelheim; PHILIPS Medical Systems; National Genome Network "NGFNplus" by the Federal Ministry of Education and Research, Germany (A301GS0833).KORA was financed by the Helmholtz Center Munich, German Research Center for Environmental Health; the German Federal Ministry of Education and Research; the State of Bavaria; the German National Genome Research Network (NGFN-2 and NGFNPlus) (01GS0823); Munich Center of Health Sciences as part of LMUinnovativ; the German Research Counsil (DFG) (WI182041 to K. O.); the genotyping costs were supported by the National Eye Institute (R01 EY020483 to D. S.) and some of the analyses were supported by the Intramural Research Program of the National Human Genome.The Kyoto Study was supported by the Japan Society for the Promotion of Science, Tokyo (21249084, 22791653).MESA and MESA SNP Health Association Resource (SHARe) are conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) (N01HC95159, N01HC95169, RR-024156, N02HL64278 (SHARe genotyping)); the National Institutes of Health (Intramural Research Program of the National Eye Institute, (ZI-AEY000403); (R01HL071205 to MESA Family); the Clinical Translational Science Institute (UL1RR033176); and the Cedars-Sinai General Clinical Research Center (RR00425). MESA thanks all investigators, especially Drs. Mary Frances Cotch, Jerome I. Rotter, Ronald Klein, and Tien Y. Wong in the Eye Working Group, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org.OGP Talana was supported by grants from the Italian Ministry of Education, University and Research (5571DSPAR2002, 718Ric2005). OGP Talana thanks the Ogliastra population and the municipal administrators for their collaboration to the project and for economic and logistic support.The Rotterdam Study and ERF were supported by the Netherlands Organisation of Scientific Research (NWO) (Vidi 91796357); Erasmus Medical Center and Erasmus University, Rotterdam, The Netherlands; Netherlands Organization for Health Research and Development (ZonMw); UitZicht; the Research Institute for Diseases in the Elderly; the Ministry of Education, Culture and Science; the Ministry for Health, Welfare and Sports; the European Commission (DG XII); the Municipality of Rotterdam; the Netherlands Genomics Initiative/NWO; Center for Medical Systems Biology of NGI; Lijf en Leven; M. D. Fonds; Henkes Stichting; Stichting Nederlands Oogheelkundig Onderzoek; Swart van Essen; Bevordering van Volkskracht; Landelijke Stichting voor Blinden en SlechtziendenBlindenhulp; Landelijke Stichting voor Blinden en Slechtzienden; Rotterdamse Vereniging voor Blindenbelangen; OOG; Algemene Nederlandse Vereniging ter Voorkoming van Blindheid; the Rotterdam Eye Hospital Research Foundation; and Topcon Europe.Rotterdam Study and ERF thank Ada Hooghart, Corina Brussee, Riet Bernaerts-Biskop, Patricia van Hilten, Pascal Arp, Jeanette Vergeer, Marijn Verkerk and Sander Bervoets. The Singapore studies (SCORM, SP2, SiMES, SINDI) were supported by the National Medical Research Council, Singapore (NMRC 07962003, NMRC 11762008), Singapore Bio-Medical Research Council (0612119466, 0913519616).The Sorbs study was supported by the Interdisciplinary Centre for Clinical Research at the University of Leipzig (B27 to A. T.) from the German Diabetes Association (to A. T.); the DHFD, Diabetes Hilfsund Forschungsfonds Deutschland (to A. T.); the European Commission under a Marie Curie Intra-European Fellowship (to R. M.); the European Community's Seventh Framework Programme (FP720072013); and ENGAGE project (HEALTHF42007201413). We thank Michael Stumvoll and Peter Kovacs for the excellent project coordination and fruitful discussion, furthermore Knut Krohn (Microarray Core Facility of the Interdisciplinary Centre for Clinical Research, University of Leipzig) for the genotyping support.TwinsUK received funding from the Wellcome Trust; the European Union MyEuropia Marie Curie Research Training Network; Guide Dogs for the Blind Association; the European Community's FP7 (HEALTHF22008201865GEFOS); ENGAGE (HEALTHF4200720 1413); the FP-5 GenomEUtwin Project (QLG2CT200201254); US National Institutes of Health/National Eye Institute (1RO1EY018246); NIH Center for Inherited Disease Research; the National Institute for Health Research comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service Foundation Trust partnering with King's College London.The Young Finns Study was financially supported by the Academy of Finland (134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi)); the Social Insurance Institution of Finland, Kuopio, Tampere; Turku University Hospital Medical Funds (grant 9M048 to T. L.); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation of Cardiovascular Research and Finnish Cultural Foundation; Tampere Tuberculosis Foundation; and Emil Aaltonen Foundation (to T.L.).