Journal article

EFFECT OF A MONOCLONAL ANTI-LYT-1.1 ON THE FUNCTIONAL-ACTIVITY OF PRECURSOR, EFFECTOR, AND REGULATORY CELLS SPECIFIC FOR MURINE ALLOANTIGENS

J SHAW, LM PILARSKI, AR ALADRA, JB LEIGH, J WILKINS, PM HOGARTH, IFC MCKENZIE, V PAETKAU

TRANSPLANTATION | WILLIAMS & WILKINS | Published : 1981

Abstract

A monoclonal anti-Lyt-1.1 serum has been characterized in terms of its effect on various cell populations involved in cell-mediated immune responses. The monoclonal serum was compared to a conventionally prepared anti-Lyt-1.1 serum. Cytotoxic T cell precursors and effectors were found to be Lyt-1.1+. Helper T cells which participate in the induction of a cytotoxic response were also Lyt-1.1+ as were suppressor T cells which inhibit cytotoxic responses. The T cell that is required for the production of a nonspecific stimulatory factor, costimulator, and that has been shown to bear the same Ly markers as does the helper T cell, bears Lyt-1.1. Finally, the effector cell which mediates delayed-t..

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