Effect of a monoclonal anti-Lyt-1.1 on the functional activity of precursor, effector, and regulatory cells specific for murine alloantigens

Abstract

A monoclonal anti-Lyt-1.1 serum has been characterized in terms of its effect on various cell populations involved in cell- mediated immune responses. The monoclonal serum was compared to a conventionally prepared anti-Lyt-1.1 serum. Cytotoxic T cell precursors and effectors were found to be Lyt-l.l+. Helper T cells which participate in the induction of a cytotoxic response were also Lyt-l.l+ as were suppressor T cells which inhibit cytotoxic responses. The T cell that is required for the production of a nonspecific stimulatory factor, costimulator, and that has been shown to bear the same Ly markers as does the helper T cell, bears Lyt-1.1. Finally, the effector cell which mediates delayed-..