Glaucoma inheritance study in Tasmania (GIST) .3. The confounding problem of overlapping pedigrees.
CH Wilkinson, RM Wilkinson, JM Barbour, J Sack, M Troski, MA Ring, RC Cooper, J Lynch, JL Rait, PJ McCartney, MA Coote, DA Mackey
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | LIPPINCOTT-RAVEN PUBL | Published : 1996
Purpose. The Glaucoma Inheritance Study in Tasmania (GIST) is a population survey of the island Tasmania (population 500,000). Its aim is to find families with autosomal dominant, adult onset, primary open angle glaucoma (POAG) suitable for genetic linkage analysis. POAG is relatively common, affecting around 3% of the Australian population over 40 years. It is possible that pedigrees may overlap, confusing the true segregation of glaucoma genes. By finding all the large families with POAG and identifying all the descendants in a captive population, it is possible that we may more easily identify overlap of different glaucoma pedigrees. Method. We studied the pedigree structures of the first..View full abstract