Glaucoma inheritance study in Tasmania (GIST) .5. Defining glaucoma for linkage studies.

Abstract

Purpose. The "GIST Score" was developed to facilitate linkage analysis of adult onset Primary Open Angle Glaucoma (POAG) pedigrees. Previous genetic linkage studies on Juvenile Open Angle Glaucoma pedigrees have relied upon an analysis of definitely affected individuals using the 'single best diagnosis' convention. Studies of adult onset POAG have been complicated by the limited numbers of affected individuals in any pedigree due to the later onset of the disease, although many members of the pedigree may have equivocal clinical features or are too young to show signs of the disease. Method. The "GIST Score" is a numeric value between 0 and 1 where 0 is clinical certainty of absence of the d..