Accuracy and implications of a reported family history of glaucoma: Experience from the glaucoma inheritance study in tasmania

Abstract

Objectives: To ascertain the prevalence of previously undiagnosed primary open-angle glaucoma (POAG) within 5 large POAG pedigrees and to evaluate the reliability of a reported family history of glaucoma within these pedigrees. Methods: The Glaucoma Inheritance Study in Tasmania (GIST) identified several large adult POAG pedigrees. Intraocular pressure (IOP), optic disc stereophotography, and automated perimetry were performed on all adult pedigree members. Participants were classified as normal (IOP <22 mm Hg and normal optic disc and field); glaucoma suspect (normal field, but an IOP ≥22 mm Hg and/or suspicious optic disc); or POAG (field defect and glaucomatous optic disc). Some individua..