Genetic Investigation into the Endophenotypic Status of Central Corneal Thickness and Optic Disc Parameters in Relation to Open-Angle Glaucoma
David P Dimasi, Kathryn P Burdon, Alex W Hewitt, Jude Fitzgerald, Jie Jin Wang, Paul R Healey, Paul Mitchell, David A Mackey, Jamie E Craig
American Journal of Ophthalmology | ELSEVIER SCIENCE INC | Published : 2012
Awarded by Australian National Health and Medical Research Council, Canberra, Australia
ALL AUTHORS HAVE COMPLETED AND SUBMITTED THE ICMJE FORM FOR DISCLOSURE OF POTENTIAL CONFLICTS OF interest and none were reported. Publication of this article was supported by grants 535077 and 535074 from the Australian National Health and Medical Research Council, Canberra, Australia. Dr Dimasi is supported by a National Health and Medical Research Council Dora Lush Postgraduate Biomedical Research Scholarship. Dr Burdon is supported by a National Health and Medical Research Council Career Development Award. Dr Mackey is a Pfizer Research Fellow. Dr Craig is supported in part by a National Health and Medical Research Council Practitioner Fellowship. Involved in Design of study (D.P.D., K.P.B., A.W.H., J.E.C.); Conduct of study (D.P.D., K.P.B., A.W.H., J.F., J.J.W., P.R.H., P.M., D.A.M., J.E.C.); Collection, management, analysis, and interpretation of data (D.P.D., K.P.B., A.W.H., J.F., J.J.W., P.R.H., P.M., DAM., J.E.C.); Preparation, review, or approval of manuscript (D.P.D., K.P.B., A.W.H., J.J.W., P.R.H., P.M., D.A.M., J.E.C.). Prospective approval for this study was obtained from the relevant human research ethics committees of the following institutions: Flinders University and Southern Adelaide Health Service, University of Tasmania, Western Sydney Area Health Service, and the University of Sydney. Approval included permission to assess participants clinically and to obtain blood for the purposes of DNA extraction and subsequent genetic analysis. Each study adhered to the tenets of the Declaration of Helsinki, and all research participants gave informed consent to be involved in the study. The authors thank Bronwyn Usher, Shari Javadiyan, and Kate Laurie, Department of Ophthalmology, Flinders University, for technical assistance.