Journal article

EFFECT OF INCREASED BILE-FLOW AND BILE-ACID SECRETION ON THE HEPATIC ELIMINATION OF SODIUM VALPROATE IN THE CAT

AW MARSHALL, GW MIHALY, RA SMALLWOOD, RG HANSON, FJE VAJDA, J PHILLIPS, J BALDAS

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | BLACKWELL SCIENCE | Published : 1984

Abstract

The effect of increased bile flow and hepatic bile acid flux on the systemic clearance and hepatic elimination of intravenously administered sodium valproate was studied in the bile fistula cat. Taurochenodeoxycholic acid (TCDC), tauro-3 alpha, 7 beta-dihydroxy-12-keto-5 beta-cholanoic acid (T12K), SC-2644, and secretin were infused intravenously to vary bile flow and biliary bile acid secretion. Control animals were infused with 0.15 mol/l NaCl. Less than 1% of the drug administered to controls appeared as unchanged valproate in the bile over 6 h. Although SC-2644, T12K, and secretin significantly increased biliary excretion of valproate, it did not exceed 2% of the intravenous dose. Biliar..

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