Journal article

Comparative genomics of the neglected human malaria parasite Plasmodium vivax

Jane M Carlton, John H Adams, Joana C Silva, Shelby L Bidwell, Hernan Lorenzi, Elisabet Caler, Jonathan Crabtree, Samuel V Angiuoli, Emilio F Merino, Paolo Amedeo, Qin Cheng, Richard MR Coulson, Brendan S Crabb, Hernando A del Portillo, Kobby Essien, Tamara V Feldblyum, Carmen Fernandez-Becerra, Paul R Gilson, Amy H Gueye, Xiang Guo Show all

Nature | NATURE PUBLISHING GROUP | Published : 2008

Abstract

The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, an..

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Grants

Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Awarded by NATIONAL LIBRARY OF MEDICINE


Funding Acknowledgements

We thank the P. vivax research community for their support, and in particular M. Gottlieb and V. McGovern for facilitating financial support. Funding came from the following sources: P. vivax sequencing, assembly and closure, US Department of Defense and National Institute of Allergy and Infectious Diseases; genome mapping, BurroughsWellcome Fund; and selective constraint analysis, National Institute of General Medical Sciences. We wish to thank TIGR's SeqCore, Closure and IFX core facilities, E. Lee, J. Sundaram, J. Orvis, B. Haas and T. Creasy for engineering support, R. K. Smith Jr for annotation support, E. Lyons and H. Zhang for technical assistance, H. Potts for statistical analysis, T. McCutchan for rDNA sequence annotation, and S. Perkins for the Plasmodium phylogeny.