Journal article
Comparative genomics of the neglected human malaria parasite Plasmodium vivax
JM Carlton, JH Adams, JC Silva, SL Bidwell, H Lorenzi, E Caler, J Crabtree, SV Angiuoli, EF Merino, P Amedeo, Q Cheng, RMR Coulson, BS Crabb, HA Del Portillo, K Essien, TV Feldblyum, C Fernandez-Becerra, PR Gilson, AH Gueye, X Guo Show all
Nature | NATURE PORTFOLIO | Published : 2008
DOI: 10.1038/nature07327
Abstract
The human malaria parasite Plasmodium vivax is responsible for 25-40% of the ∼515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that t..
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Awarded by Burroughs Wellcome Fund
Funding Acknowledgements
We thank the P. vivax research community for their support, and in particular M. Gottlieb and V. McGovern for facilitating financial support. Funding came from the following sources: P. vivax sequencing, assembly and closure, US Department of Defense and National Institute of Allergy and Infectious Diseases; genome mapping, BurroughsWellcome Fund; and selective constraint analysis, National Institute of General Medical Sciences. We wish to thank TIGR's SeqCore, Closure and IFX core facilities, E. Lee, J. Sundaram, J. Orvis, B. Haas and T. Creasy for engineering support, R. K. Smith Jr for annotation support, E. Lyons and H. Zhang for technical assistance, H. Potts for statistical analysis, T. McCutchan for rDNA sequence annotation, and S. Perkins for the Plasmodium phylogeny.