Journal article

Estimating glomerular filtration rate in diabetes: a comparison of cystatin-C- and creatinine-based methods

RJ MacIsaac, C Tsalamandris, MC Thomas, E Premaratne, S Panagiotopoulos, TJ Smith, A Poon, MA Jenkins, SI Ratnaike, DA Power, G Jerums

DIABETOLOGIA | SPRINGER | Published : 2006


AIMS/HYPOTHESIS: We compared the predictive performance of a GFR based on serum cystatin C levels with commonly used creatinine-based methods in subjects with diabetes. SUBJECTS, MATERIALS AND METHODS: In a cross-sectional study of 251 consecutive clinic patients, the mean reference (plasma clearance of (99m)Tc-diethylene-triamine-penta-acetic acid) GFR (iGFR) was 88+/-2 ml min(-1) 1.73 m(-2). A regression equation describing the relationship between iGFR and 1/cystatin C levels was derived from a test population (n=125) to allow for the estimation of GFR by cystatin C (eGFR-cystatin C). The predictive performance of eGFR-cystatin C, the Modification of Diet in Renal Disease 4 variable formu..

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