Electroanatomic remodelling of the pulmonary veins associated with age

AW Teh; JM Kalman; G Lee; C Medi; PM Heck; LH Ling; S Kumar; SJ Spence; JB Morton; PM Kistler

Journal article

Electroanatomic remodelling of the pulmonary veins associated with age

AW Teh, JM Kalman, G Lee, C Medi, PM Heck, LH Ling, S Kumar, SJ Spence, JB Morton, PM Kistler

Europace | OXFORD UNIV PRESS | Published : 2012

DOI: 10.1093/europace/eur275

Abstract

Aims: : Increasing age is a significant risk factor for developing atrial fibrillation (AF). Pulmonary vein (PV) triggers are critical in the mechanism of AF, but little is known of the substrate changes that occur within the PVs with ageing. Therefore, we sought to identify whether ageing is associated with electroanatomic changes within the pulmonary veins. Methods and Results: : Twenty-five patients undergoing ablation for left-sided supraventricular tachycardia had high-density 3D electroanatomic maps of all four PVs created. Patients were divided into two groups: group 1 aged 50 years. Mean-voltage (MV), low-voltage (LV < 0.5 mV), conduction, signal complexity, and PV muscle sleeve leng..

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University of Melbourne Researchers

Jonathan Kalman Author

Geoffrey Lee Author

Han Ling Author

Peter Kistler Author

Grants

Funding Acknowledgements

[ "A.W.T., C.M., and L-H.L. are the recipients of a postgraduate research scholarship from the National Heart Foundation of Australia. S.K. and G.L. are the recipients of a postgraduate research scholarship from the National Health and Medical Research Council. A.W.T., C.M., and L-H. L. are the recipients of a cardiovascular and lipid research grant from Pfizer. P.M.K. is supported by a Research Investigatorship from the Cardiac Society of Australia and New Zealand.", "This research was supported in part by the Victoria Government's OIS Program." ]