Journal article
Diagnostic imaging of Alzheimer's disease with copper and technetium complexes
James L Hickey, Paul S Donnelly
COORDINATION CHEMISTRY REVIEWS | ELSEVIER SCIENCE SA | Published : 2012
Abstract
The most common form of dementia is Alzheimer's disease, a progressive neurodegenerative disease that leads to synaptic failure and neuronal death. This review discusses the development of copper and technetium coordination complexes designed as radiopharmaceuticals to assist in the diagnosis of Alzheimer's disease using positron emission tomography or single photon emission computed tomography. Technetium complexes used to image regional brain perfusion are discussed as well as copper and technetium complexes specifically designed to bind to amyloid-β plaques that are associated with the onset of symptoms of the disease. © 2012 Elsevier B.V.
Grants
Funding Acknowledgements
Ms. SinChun Lim, Dr. Michelle T. Fodero-Tavoletti, Dr. Victor L. Villemagne and A.Prof. Kevin J. Barnham (all from the University of Melbourne) are thanked for their vital contributions to our ongoing collaborative research in this area. Financial support from the Australian Research Council and the National Health and Medical Research Council (Australia) is greatly appreciated.