Fenofibrate - A Potential Systemic Treatment for Diabetic Retinopathy?

Abstract

PURPOSE: To review clinical and experimental data for fenofibrate as a possible systemic treatment for diabetic retinopathy. DESIGN: Perspective. METHODS: Review of clinical studies focused on 2 major randomized controlled trials: the FIELD (Fenofibrate Intervention and Event Lowering in Diabetes) and ACCORD (Action to Control Cardiovascular Risk in Diabetes)-Eye studies. Progression was defined in FIELD as laser treatment for proliferative retinopathy or macular edema or increase by ≥ 2 steps on the Early Treatment Diabetic Retinopathy Study (ETDRS) scale, and in ACCORD-Eye as ≥ 3 steps (ETDRS scale) or proliferative disease requiring laser or vitrectomy treatment. Experimental studies inve..