Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

Onisha Patel; Daniel G Pellicci; Stephanie Gras; Maria L Sandoval-Romero; Adam P Uldrich; Thierry Mallevaey; Andrew J Clarke; Jerome Le Nours; Alex Theodossis; Susanna L Cardell; Laurent Gapin; Dale I Godfrey; Jamie Rossjohn

Journal article

Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor

Onisha Patel, Daniel G Pellicci, Stephanie Gras, Maria L Sandoval-Romero, Adam P Uldrich, Thierry Mallevaey, Andrew J Clarke, Jerome Le Nours, Alex Theodossis, Susanna L Cardell, Laurent Gapin, Dale I Godfrey, Jamie Rossjohn

NATURE IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2012

DOI: 10.1038/ni.2372

University of Melbourne Researchers

Dale Godfrey Author Microbiology and Immunology

Adam Uldrich Author Microbiology and Immunology

Daniel Pellicci Author Microbiology and Immunology

Related Projects (4)

IMMUNE REGULATION EFFECTOR FUNCTION AND THERAPY

We seek to understand how white blood cells detect and destroy disease, and how molecules of the immune system punch holes in diseased cells..

Self-reactivity by NKT cells

NKT cells are a type of lymphocyte with the ability to prevent a broad range of diseases including cancer, autoimmunity, infection and graft..

RESEARCH FELLOWSHIP

Professor Godfrey is an immunologist with a long standing history as a pioneer in the study of a specialised type of white blood cell, known..

IMMUNE REGULATION EFFECTOR FUNCTION AND THERAPY

We seek to understand how white blood cells detect and destroy disease, and how molecules of the immune system punch holes in diseased cells..

Grants

Awarded by US National Institutes of Health

Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Funding Acknowledgements

We thank the staff at the MX2 beamline of the Australian synchrotron for assistance with data collection and Monash Macromolecular Crystallisation Facility for crystallization experiments. Supported by the National Health and Medical Research Council of Australia (D.I.G. and J.R.), the Australian Research Council, the Cancer Council of Victoria, the US National Institutes of Health (AI090450 and AI092108 to L.G.), the Swedish Research Council (S.L.C.), the Swedish Cancer Society (S.L.C.) and Monash University (S.C. and J.R.).