DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa
Jeffrey B Kerr, Karla J Hutt, Ewa M Michalak, Michele Cook, Cassandra J Vandenberg, Seng H Liew, Philippe Bouillet, Alea Mills, Clare L Scott, Jock K Findlay, Andreas Strasser
Molecular Cell | CELL PRESS | Published : 2012
Awarded by National Health and Medical Research Council (NHMRC Australia)
Awarded by Leukemia and Lymphoma Society (New York)
Awarded by National Cancer Institute (NIH)
Awarded by NATIONAL CANCER INSTITUTE
We thank Professors J.M. Adams, S. Cory, and A. Villunger for gifts of mice, G. Tarulli and H. Morgan for assistance with histology, and E. Jansen for technical assistance and Drs. G. Enders, R. Schultz, and F. McKeon for gifts of antibodies. This work was supported by fellowships and grants from the National Health and Medical Research Council (NHMRC Australia; project grants #1006460 and #1007027, program grants #494802 and #257502, and fellowships to J.K.F. [#441101], K.J.H. [#494836], C.L.S. [#406675], and A.S. [#461299]), the Cancer Council Victoria (E.M.M. and Sir Edward Dunlop Cancer Research Fellow to C.L.S.), the Leukemia and Lymphoma Society (New York; SCOR grant #7015), the National Cancer Institute (NIH; CA 43540), the American Cancer Society (A.A.M.), and the Victorian Cancer Agency (Clinical Fellowship to C.L.S.). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institutes Infrastructure Support Scheme (IRIISS). J.B.K., K.J.H., and E.M.M. performed and planned experiments, interpreted data, and wrote the manuscript. M.C., C.V., and S.H.L. helped with experiments and contributed data. P.B. and A.M. contributed essential reagents and helped with interpretation of results and manuscript writing. A.S., J.K.F., and C.L.S. conceived of the study, planned experiments, interpreted data, and wrote the manuscript.