Journal article
Perioperative amplitude-integrated EEG and neurodevelopment in infants with congenital heart disease
JK Gunn, J Beca, RW Hunt, M Olischar, LS Shekerdemian
Intensive Care Medicine | SPRINGER | Published : 2012
Abstract
Purpose: Perioperative brain injury is common in young infants undergoing cardiac surgery. We aimed to determine the relationship between perioperative electrical seizures, the background pattern of amplitude-integrated electroencephalography (aEEG) and 2-year neurodevelopmental outcome in young infants undergoing surgery for congenital heart disease. Methods: A total of 150 newborn infants undergoing cardiac surgery underwent aEEG monitoring prior to and during surgery, and for 72 h postoperatively. Two blinded assessors reviewed the aEEGs for seizure activity and background pattern. Survivors underwent neurodevelopmental outcome assessment using the Bayley Scales of Infant Development (3rd..
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Funding Acknowledgements
Thank you to the following people for their assistance with data collection (the Hearts and Minds Study research nurses in Melbourne and Auckland, particularly Michelle Goldsworthy, Laura-Clare Whelan, Stephen McKeever and Carmel Delzoppo) and for their support of our study (the cardiac surgeons, anaesthetists, perfusionists and paediatric intensive care staff of both hospitals). We are also appreciative of Prof Terrie Inder for her involvement in the original study design. Funding support was received from the National Heart Foundation (Australia), Heart Foundation of New Zealand, Auckland Medical Research Fund, Green Lane Research and Education Fund, Australian and New Zealand Intensive Care Foundation, Murdoch Childrens Research Institute (MCRI) and the Victorian Government's Operational Infrastructure Support Program. Dr Gunn received a postgraduate health research scholarship from National Health and Medical Research Council (NHMRC) and MCRI.