Plasmodium falciparum Apicoplast Drugs: Targets or Off-Targets?
Cyrille Y Botte, Faustine Dubar, Geoffrey I McFadden, Eric Marechal, Christophe Biot
CHEMICAL REVIEWS | AMER CHEMICAL SOC | Published : 2012
The potential of several pathways and lead molecules explored in the last 15 years are reviewed. In the light of new insights, it is discussed if the apicoplast is the Achilles' heel of the malaria parasite. Quinolones and fluoroquinolones were reported to be active against P. falciparum. A study showed that only the combination of the three drugs is safe and efficacious for treating malaria in P. bergheiinfected mice. Doxycycline is recommended in the second-line treatment of uncomplicated P. falciparum malaria and in the treatment of severe malaria in combination with artesunate or quinine for seven days. The use of fosmidomycin has helped understanding the fate of some precursors of the a..View full abstract
This work was supported by CaP (Consortium Anti-Parasitaire/Chemotherapy Against Parasites), the CNRS, the Universite de Lille 1, the Ministere de l'Enseignement Superieur (grant attributed to F.D.), Agence nationale de la recherche (PlasmoExplore and ReGal grants attributed to E.M.), and the National Health and Medical Research Council of Australia (G.I.M.). C.Y.B. was supported by an FP7 OIF Marie Curie Fellowship (ERC) and an Endeavour Fellowship (DEST). G.I.M. is a Federation Fellow of the Australian Research Council and a Howard Hughes International Scholar.