Journal article
Substance P and vasoactive intestinal peptide are reduced in right transverse colon in pediatric slow-transit constipation
SK King, JR Sutcliffe, SY Ong, M Lee, TL Koh, SQ Wong, PJ Farmer, CJ Peck, MP Stanton, J Keck, DJ Cook, CW Chow, JM Hutson, BR Southwell
Neurogastroenterology and Motility | Published : 2010
Abstract
Background Slow-transit constipation (STC) is recognized in children but the etiology is unknown. Abnormalities in substance P (SP), vasoactive intestinal peptide (VIP) and nitric oxide (NO) have been implicated. The density of nerve fibers in circular muscle containing these transmitters was examined in colon from children with STC and compared to other pediatric and adult samples. Methods Fluorescence immunohistochemistry using antibodies to NO synthase (NOS), VIP and SP was performed on colonic biopsies (transverse and sigmoid colon) from 33 adults with colorectal cancer, 11 children with normal colonic transit and anorectal retention (NAR) and 51 with chronic constipation and slow motili..
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Awarded by NHMRC Australia
Funding Acknowledgements
Supported by grants (114215, 216704) and Senior Research Fellowship (436916) from NHMRC Australia, PhD scholarships (SKK) from Royal Australasian College of Surgeons and NHMRC, Murdoch Childrens Research Institute and King's Fund London (MPS). Thanks to Dr. Patricia Hengel and Mark Antonello for early studies and quantification. There are no other financial interests. Presented at the American Gastroenterology Association Annual meeting, 2008 [Gastroenterology 134 (4) S1: 420. M1793] and the American Motility Society Annual meeting, 2006 [Neurogastroenterology and Motility 18 (8) 669. A13, 2006].