Plasma and breast milk concentrations of dothiepin and northiaden in lactating women

Abstract

Plasma and breast‐milk concentrations of dothiepin and its metabolite northiaden were measured in 20 lactating women receiving the drug for post‐partum depression. Samples were collected at steady‐state and both compounds quantitated by HPLC. Doses of dothiepin varied from 75 mg/day to 225 mg/day. Accordingly a wide range of plasma and breast‐milk concentrations of dothiepin and northiaden were determined. Most determinations were made for women receiving 150 mg/day. At this dose mean (± SD) plasma concentrations of dothiepin and northiaden were 56(±27)m̈g/l and 72(±79)m̈g/l respectively while breast‐milk concentrations were 95(±71) m̈g/l and 40(±29) m̈g/l for dothiepin and northiaden respec..