Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?
JE Noll, SA Williams, LE Purton, ACW Zannettino
BLOOD CANCER JOURNAL | NATURE PUBLISHING GROUP | Published : 2012
In the adult mammal, normal haematopoiesis occurs predominantly in the bone marrow, where primitive haematopoietic stem cells (HSC) and their progeny reside in specialised microenvironments. The bone marrow microenvironment contains specific anatomical areas (termed niches) that are highly specialised for the development of certain blood cell types, for example HSCs. The HSC niche provides important cell-cell interactions and signalling molecules that regulate HSC self-renewal and differentiation processes. These same signals and interactions are also important in the progression of haematological malignancies, such as multiple myeloma (MM). This review provides an overview of the bone marro..View full abstract
LEP is an NHMRC Senior Research Fellow. LEP is the recipient of a project grant from NHMRC and is supported by the Victorian Government's Operational Infrastructure Support Program. ACWZ is supported by grants from the NHMRC, Cancer Australia, Leukaemia Foundation of Australia and the Cancer Council of South Australia.