Journal article
Magnetic resonance spectroscopy and neurocognitive dysfunction in obstructive sleep apnea before and after CPAP treatment
FJ O'Donoghue, RM Wellard, PD Rochford, A Dawson, M Barnes, WR Ruehland, ML Jackson, ME Howard, RJ Pierce, GD Jackson
Sleep | OXFORD UNIV PRESS INC | Published : 2012
DOI: 10.5665/sleep.1582
Abstract
Study Objectives: To determine whether cerebral metabolite changes may underlie abnormalities of neurocognitive function and respiratory control in OSA. Design: Observational, before and after CPAP treatment. Setting: Two tertiary hospital research institutes. Participants: 30 untreated severe OSA patients, and 25 age-matched healthy controls, all males free of comorbidities, and all having had detailed structural brain analysis using voxel-based morphometry (VBM). Measurements and Results: Single voxel bilateral hippocampal and brainstem, and multivoxel frontal metabolite concentrations were measured using magnetic resonance spectroscopy (MRS) in a high resolution (3T) scanner. Subjects als..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
[ "Supported by National Health and Medical Research Council of Australia grants number 226200 and 430300, by ResMed Pty and the Austin Hospital Medical Research Foundation. The authors are grateful to the sleep physicians at Austin Health and to Dr. James Jamieson for help in recruiting OSA patients.", "This study was funded in part by ResMed Australia. Dr. Rochford has received research support from Compumedics and ResMed Australia. Dr. Ruehland has received research support from ResMed Australia, Fisher and Paykel Healthcare, and Philips Respironics. Dr. Howard has received loans of equipment from Sleep Diagnostics and Edansafe. The other authors have indicated no financial conflicts of interest." ]