Journal article
Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster
CC Milton, X Zhang, NO Albanese, KF Harvey
Development | Published : 2010
DOI: 10.1242/dev.042309
Abstract
The Salvador-Warts-Hippo (SWH) pathway contains multiple growth-inhibitory proteins that control organ size during development by limiting activity of the Yorkie oncoprotein. Increasing evidence indicates that these growth inhibitors act in a complex network upstream of Yorkie. This complexity is emphasised by the distinct phenotypes of tissue lacking different SWH pathway genes. For example, eye tissue lacking the core SWH pathway components salvador, warts or hippo is highly overgrown and resistant to developmental apoptosis, whereas tissue lacking fat or expanded is not. Here we explore the relative contribution of SWH pathway proteins to organ size control by determining their temporal a..
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Funding Acknowledgements
We thank F. Grusche and H. Richardson for comments; M. Betson, S. Cohen, R. Fehon, G. Halder, I. Hariharan, B. Hay, K. Irvine, A. Laughon, F. Martin, D. Pan, J. Price, P. Sinha, N. Tapon, the Developmental Studies Hybridoma Bank, the Vienna Drosophila RNAi Centre, the Australian Drosophila Research Support Facility (www.ozdros.com) and the Bloomington Stock Center for fly stocks and antibodies; and the Peter Mac Microscopy core for assistance. K. F. H. holds Career Development Awards from the International Human Frontier Science Program Organization and the National Health and Medical Research Council of Australia. This work was supported by a Project Grant from the National Health and Medical Research Council of Australia and a Discovery Grant from the Australian Research Council.