Journal article

Cortical and thalamic resting-state functional connectivity is altered in childhood absence epilepsy

Richard A Masterton, Patrick W Carney, Graeme D Jackson



PURPOSE: Functional imaging studies have identified a common network of brain regions that activate and deactivate during the generalised spike wave (GSW) discharges of childhood absence epilepsy (CAE). Functional connectivity within this network is also altered during the resting state. In this study our aim was to assess functional connectivity throughout the whole brain of patients with CAE. METHODS: We studied a group of eleven patients with untreated CAE and eleven matched controls using resting-state fMRI. We measured functional connectivity between every pair of voxels and generated images of "whole-brain" functional connectivity by counting the number of functional connections of eac..

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Awarded by National Health & Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

We thank the participants and their families for involvement in this study; Simon Harvey and the Neurology Departments of the Royal Children's Hospital and the Austin Hospital for assistance with patient recruitment; Danny Flanagan for assistance with EEG recording, reporting and analysis and Jan Barchett for assistance with EEG. This study was supported by the National Health & Medical Research Council of Australia (NHMRC) Program Grant 400121; a Pfizer Inc. Neuroscience Research Grant; and the Operational Infrastructure Support Program of the State Government of Victoria. P.W.C. was supported by a Dowd Foundation Scholarship.