BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics

Abstract

Background: BRAF mutations in colorectal cancer (CRC) are disproportionately observed in tumors exhibiting microsatellite instability (MSI) and are associated with other prognostic factors. The independent association between BRAF mutation status and CRC survival, however, remains unclear. Methods: We evaluated the association between the BRAF c.1799T>A (p.V600E) mutation and survival in individuals with incident invasive CRC diagnosed between 1997 and 2007 in Western Washington State. Tumor specimens were tested for this BRAF mutation and MSI status. Weused Cox regression to estimate HRs and 95% confidence intervals (CI) for the association between BRAF mutation status and disease-specific ..