Journal article
Discrepancy between minimal inhibitory concentration to enrofloxacin and mutations present in the quinolone-resistance determining regions of Mycoplasma gallisepticum field strains
I Lysnyansky, I Gerchman, S Levisohn, I Mikula, A Feberwee, NM Ferguson, AH Noormohammadi, J Spergser, HM Windsor
Veterinary Microbiology | Published : 2012
Abstract
Molecular characterization of the quinolone-resistance determining regions (QRDRs) of DNA gyrase and topoisomerase IV in 93 Mycoplasma gallisepticum field strains isolated in different geographic regions revealed discrepancies between minimal inhibitory concentration values and presence of amino acid substitutions within the QRDRs of GyrA and ParC in 9/93 (10%) strains. This may delimitate applicability of a gene-based assay to detect fluoroquinolone resistance in this avian pathogen. © 2012 Elsevier B.V.
Grants
Awarded by Israel Egg and Poultry Board
Funding Acknowledgements
This study was supported by Research Grant Award 847-0346 from the Israel Egg and Poultry Board.