Journal article

The Antibacterial Effect of a Proline-Rich Antibacterial Peptide A3-APO

F Rozgonyi, D Szabo, B Kocsis, E Ostorhazi, G Abbadessa, M Cassone, JD Wade, L Otvos

CURRENT MEDICINAL CHEMISTRY | BENTHAM SCIENCE PUBL LTD | Published : 2009

Abstract

Antimicrobial resistance is an emerging worldwide concern in light of the widespread antimicrobial drug use in humans, livestock and companion animals. The treatment of life-threatening infections is especially problematic because clinical strains rapidly acquire multiple-drug resistance. Antimicrobial peptides have long been considered to be viable alternatives to small molecule antibiotics. However, the peptides' parenteral use is frequently hampered by inadequate safety margins and rapid renal clearance leaving them suitable only for topical applications. The proline-rich peptide A3-APO represents a family of a new class of synthetic dimers that kill bacteria by a dual mode of action and ..

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