Journal article
Role of the energy sensor AMP-activated protein kinase in renal physiology and disease
KR Hallows, PF Mount, NM Pastor-Soler, DA Power
American Journal of Physiology Renal Physiology | Published : 2010
Abstract
The ultrasensitive energy sensor AMP-activated protein kinase (AMPK) orchestrates the regulation of energy-generating and energy-consuming pathways. AMPK is highly expressed in the kidney where it is reported to be involved in a variety of physiological and pathological processes including ion transport, podocyte function, and diabetic renal hypertrophy. Sodium transport is the major energy-consuming process in the kidney, and AMPK has been proposed to contribute to the coupling of ion transport with cellular energy metabolism. Specifically, AMPK has been identified as a regulator of several ion transporters of significance in renal physiology, including the cystic fibrosis transmembrane con..
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Awarded by National Institute of Diabetes and Digestive and Kidney Diseases
Funding Acknowledgements
This work was supported by National Institutes of Health Grants R01 DK075048 (to K. R. Hallows) and R01 DK084184 (to N. M. Pastor-Soler), American Heart Association Grant AHA 09GRNT2060539 (to N. M. Pastor-Soler), and project grant 434109 from the Australian National Health and Medical Research Association (to D. A. Power). N. M. Pastor-Soler is a recipient of the American Society of Nephrology Carl W. Gottschalk Research Scholar Grant.