Benign Neonatal Sleep Myoclonus: An Autosomal Dominant Form Not Allelic to KCNQ2 or KCNQ3
Zaid Afawi, Haim Bassan, Sarah Heron, Karen Oliver, Rachel Straussberg, Ingrid Scheffer, Richard Leventer, Amos Korczyn, Samuel Berkovic
JOURNAL OF CHILD NEUROLOGY | SAGE PUBLICATIONS INC | Published : 2012
Benign neonatal sleep myoclonus is an uncommon, nonepileptic disorder characterized by myoclonic jerks appearing in the neonatal period that occur predominantly during sleep. Although self-limiting, the disorder is frequently confused with epileptic neonatal seizures. A few familial cases have been reported; however the genetics has not been studied. We ascertained 3 families with 2 or more affected individuals and analyzed the pedigrees. We used microsatellite markers to determine if the disorder was possibly linked to KCNQ2 or KCNQ3, the 2 genes that cause most cases of benign familial neonatal seizures, a disorder that it could be easily confused with. The 3 pedigrees, including one with ..View full abstract
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Awarded by National Health and Medical Research Council of Australia
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by a Program Grant (ID: 400121) from the National Health and Medical Research Council of Australia.