Urinary biomarkers in septic acute kidney injury

Abstract

Objective: To appraise the literature on the value of urinary biomarkers in septic acute kidney injury (AKI). Design: Systematic review. Setting: Academic medical centre. Patients and participants: Human studies of urinary biomarkers. Interventions: None. Measurements and results: Fourteen articles fulfilled inclusion criteria. Most studies were small, single-centre, and included mixed medical/surgical adult populations. Few focused solely on septic AKI and all had notable limitations. Retrieved articles included data on low-molecular-weight proteins (β2-microglobulin, α1-microglobulin, adenosine deaminase binding protein, retinol binding protein, cystatin C, renal tubular epithelial antigen..