Journal article
B cell memory to a serogroup C meningococcal conjugate vaccine in childhood and response to booster: Little association with serum IgG antibody
KP Perrett, C Jin, E Clutterbuck, TM John, AP Winter, E Kibwana, LM Yu, N Curtis, AJ Pollard
Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2012
Abstract
The maintenance of adequate serum Ab levels following immunization has been identified as the most important mechanism for individual long-term protection against rapidly invading encapsulated bacteria. The mechanisms for maintaining adequate serum Ab levels and the relationship between Ag-specific memory B cells and Ab at steady state are poorly understood.We measured the frequency of circulating serogroup C meningococcal (MenC)-specific memory B cells in 250 healthy 6- to 12-y-old children 6 y following MenC conjugate vaccine priming, before a booster of a combined Haemophilus influenzae type b-MenC conjugate vaccine and then 1 wk, 1 mo, and 1 y after the booster. We investigated the relat..
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Funding Acknowledgements
[ "This work was supported by the National Institute for Health Research, Oxford Biomedical Research Centre, Thames Valley Comprehensive Local Research Network, GlaxoSmithKline Vaccines, and the European Society of Infectious Diseases. A.J.P. is a Jenner Institute Investigator and a James Martin Senior Fellow.", "A.J.P. has conducted clinical trials on behalf of Oxford University sponsored by manufacturers of vaccines. A.J.P. does not accept any personal payments from vaccine manufacturers; honoraria, travel expenses, and grants for support of educational activities are paid to an educational/administrative fund held by the Department of Paediatrics, University of Oxford. K. P. P. has received assistance to attend scientific meetings from Novartis. The study was partly funded by GlaxoSmithKline. All other authors have no financial conflicts of interest." ]