Journal article

The Impact of a Large and Frequent Deletion in the Human TCR beta Locus on Antiviral Immunity

Rebekah M Brennan, Jan Petersen, Michelle A Neller, John J Miles, Jacqueline M Burrows, Corey Smith, James McCluskey, Rajiv Khanna, Jamie Rossjohn, Scott R Burrows

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2012

Abstract

The TCR plays a critical role in recognizing intracellular pathogens and initiating pathways leading to the destruction of infected cells by the immune system. Although genetic variability is known to greatly impact on the human immune system and the outcome of infection, the influence of sequence variation leading to the inactivation or deletion of TCR gene segments is unknown. To investigate this issue, we examined the CD8(+) T cell response to an HLA-B7-restricted epitope ((265)RPHERNGFTVL(275)) from the pp65 Ag of human CMV that was highly biased and frequently dominated by a public TCR β-chain encoded by the variable gene segment TRBV4-3. Approximately 40% of humans lack T cells express..

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University of Melbourne Researchers