Journal article

EFFECTS OF AGING ON SENSORY NERVE FUNCTION IN RAT SKIN

Z KHALIL, V RALEVIC, M BASSIRAT, GJ DUSTING, RD HELME

BRAIN RESEARCH | ELSEVIER SCIENCE BV | Published : 1994

Abstract

Human studies have shown an age-related decrease in modulation of skin vascular reactivity by sensory nerves that correlates with a decline in wound repair efficacy. Using a vacuum-induced blister model in the rat hind footpad, we have investigated age-related changes in pre- and post-terminal activity of primary afferents involved in skin neurovascular function. Changes in local skin blood flow were monitored using a laser Doppler flowmeter. Pre-terminal stimulation was achieved by electrical stimulation of the distal end of the sciatic nerve (10 V, 15 Hz and 0.5 ms) in three groups of young, old and neonatally pretreated capsaicin rats (3, 24 and 3 months old, respectively). The effect of ..

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