Journal article

PHYSIOLOGICAL AND BIOCHEMICAL EFFECTS OF PREGNANCY IN UNINEPHRECTOMIZED RABBITS

DK PACKHAM, TD HEWITSON, JA WHITWORTH, PS KINCAIDSMITH

CLINICAL AND EXPERIMENTAL HYPERTENSION PART B-HYPERTENSION IN PREGNANCY | MARCEL DEKKER INC | Published : 1991

Abstract

A model of mild, persistent renal impairment was produced following uninephrectomy in 6 month old female New Zealand white rabbits infected with Encephalitozoon cuniculi. The effect of three consecutive pregnancies was assessed. No difference in plasma creatinine, creatinine clearance or total protein excretion was found at 15 months of age between 5 uninephrectomized pregnant rabbits and 5 uninephrectomized virgin animals. Mean plasma urea (11.6 ± 0.4 mmol/l) was higher at 15 months of age in 5 uninephrectomized pregnant rabbits than in 5 uninephrectomized virgin animals (7.7 ± 0.7 mmol/l)(p<0.001). During pregnancy plasma urea fell in both uninephrectomized pregnant and control pregnant an..

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