Journal article

Combining etanercept with traditional agents in the treatment of psoriasis: a review of the clinical evidence

PA Foley, C Quirk, JR Sullivan, C Dolianitis, SP Hack, K Thirunavukkarasu, AJ Cooper

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | WILEY | Published : 2010

Abstract

Psoriasis is a chronic, systemic inflammatory disorder manifesting primarily in skin and potentially in joints, frequently necessitating treatment with conventional systemic therapies, phototherapy or biological agents. Patients with moderate to severe disease suffer a diminished quality of life, experience significant comorbidities and have a higher mortality. Although traditional treatments are effective in the short-term, their use is often limited by concerns over long-term toxicity, including end-organ damage and risk of malignancy. Combination therapy is a commonly used approach and is often more effective than any single agent. Lower doses of two treatments in combination can also min..

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