Hormones and sexuality: Effect of estrogen and progestogen

Abstract

This study was planned to determine the effects of estrogen and progestogen on female sexual behavior. Forty-nine women who had undergone hysterectomy and bilateral salpingo- oophorectomy took part in a double-blind placebocontrolled cross-over study. Over a 12-month period each woman received 3 months each of ethiny1 estradiol, 50 jug per day, levonorgestrel, 250 jug per day, combination of these 2 substances (Nordiol), and a placebo. Significant differences between medications were found in sexual desire, enjoyment, and orgasmic frequency. The most beneficial effects occurred during medication with ethinyl estradiol. There were no differences observed in the effect of hormones or placebo o..