Journal article

EFFECT OF CIMETIDINE AND RANITIDINE ON CARBAMAZEPINE AND SODIUM VALPROATE PHARMACOKINETICS

LK WEBSTER, GW MIHALY, DB JONES, RA SMALLWOOD, JA PHILLIPS, FJ VAJDA

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | SPRINGER VERLAG | Published : 1984

Abstract

The pharmacokinetics of a single oral dose (400 mg) of carbamazepine and sodium valproate were compared in peptic ulcer patients before and after four weeks of a therapeutic course of either cimetidine (1 g/day, n = 6 subjects) or ranitidine (300 mg/day, n = 6 subjects). There was a small (up to 20%) but statistically significant decrease in oral clearance of carbamazepine after cimetidine treatment. A similar fall in sodium valproate clearance in five cimetidine-treated patients was accompanied by a significantly prolonged elimination half-life. No such trends were demonstrated during ranitidine treatment. Since both anticonvulsants are partly metabolized by hepatic mixed function oxidases,..

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