Cells in the female retrotrapezoid region upregulate c-fos in response to 10%, but not 5%, carbon dioxide
Mary M Niblock, Kelly M Lohr, Melissa Nixon, Caitlin Barnes, Meredith Schaudies, Mark Murphy
BRAIN RESEARCH | ELSEVIER SCIENCE BV | Published : 2012
The retrotrapezoid nucleus (RTN) is thought to regulate breathing in response to changes in blood carbon dioxide (CO(2)), and to make a vital contribution to respiratory drive, especially during sleep. However, cells in the female RTN fail to upregulate c-fos in response to low level CO(2) exposure, while cells in the male RTN have a robust upregulation of c-fos in response to low level CO(2) exposure. In this study, we examined the possibility that the female RTN has a higher threshold for c-fos upregulation in response to CO(2). Following exposure of Fos-Tau-LacZ (FTL) transgenic mice to 10% CO(2), c-fos was upregulated in just as many cells in the female as in the male RTN. In addition, t..View full abstract
This work was funded by student-faculty research grants and start-up funds (MMN) from Dickinson College, Carlisle, PA. The authors wish to thank Dr. Eugene Nattie for helpful comments on the manuscript and Ms. Katie Landis for her care of the FTL transgenic mouse colony at Dickinson.