Journal article

Histone Deacetylases and Their Role in Asthma

Simon G Royce, Tom C Karagiannis



OBJECTIVE: The aim of this article is to provide an overview of the classical histone deacetylase (HDAC) enzymes and HDAC inhibitors. The discussion is focused on the potential anti-asthmatic effects of this group of compounds. METHODS: Medline was used with the search terms, "asthma and HDAC," "asthma and Trichostatin A," "asthma and valproic acid," "allergic airways disease and HDAC," "allergic airways disease and Trichostatin A," and "allergic airways disease and valproic acid." Manuscripts from the past decade were accessed. Historical literature dating from the 1960s was accessed for the use of anti-epileptics in the treatment of asthma. RESULTS: Preliminary clinical trials with anti-ep..

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Funding Acknowledgements

The support of the Australian Institute of Nuclear Science and Engineering is acknowledged. TCK was the recipient of AINSE awards. Epigenomic Medicine Laboratory is supported by the National Health and Medical Research Council of Australia. KV is supported by a Baker IDI postgraduate scholarship, which is supported in part by the Victorian Government's Operational Infrastructure Support Program. The authors acknowledge the use of the facilities provided by Monash Micro Imaging at AMREP and particularly, the expert assistance from Drs Stephen Cody and Iska Carmichael.