Journal article
Common genetic variants in prostate cancer risk prediction - Results from the NCI breast and prostate cancer cohort consortium (BPC3)
S Lindström, FR Schumacher, D Cox, RC Travis, D Albanes, NE Allen, G Andriole, SI Berndt, H Boeing, HB Bueno-de-Mesquita, ED Crawford, WR Diver, JM Gaziano, GG Giles, E Giovannucci, CA Gonzalez, B Henderson, DJ Hunter, M Johansson, LN Kolonel Show all
Cancer Epidemiology Biomarkers and Prevention | Published : 2012
Abstract
Background: One of the goals of personalized medicine is to generate individual risk profiles that could identify individuals in the population that exhibit high risk. The discovery of more than two-dozen independent single-nucleotide polymorphism markers in prostate cancer has raised the possibility for such risk stratification. In this study, we evaluated the discriminative and predictive ability for prostate cancer risk models incorporating 25 common prostate cancer genetic markers, family history of prostate cancer, and age. Methods: We fit a series of risk models and estimated their performance in 7,509 prostate cancer cases and 7,652 controls within the National Cancer Institute Breast..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by the U.S. NIH, National Cancer Institute (cooperative agreements U01-CA98233-07 to D.J. Hunter, U01-CA98710-06 to M.J. Thun, U01-CA98216-06 to E. Riboli and R. Kaaks, and U01-CA98758-07 to B. E. Henderson and Intramural Research Program of NIH/National Cancer Institute, Division of Cancer Epidemiology and Genetics).