Clioquinol Protects Against Cell Death in Parkinson's Disease Models In Vivo and In Vitro

Abstract

Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons located in the substantia nigra (SN). Data from our group and others indicate that metals, oxidative stress, and bioavailable reductants provide a possible mechanism for the neurodegeneration observed in PD. 6-Hydroxydopamine (6-OHDA) injection into the nigra of mice resulted in quantified loss of dopaminergic neurons. Oral administration of the metal–protein binding compound clioquinol (CQ) commencing on the day of lesion led to a significant reduction in lesion size. This finding elaborates upon our previous study that long-term pre-treatment with CQ reduced the susceptibility of SN neurons to another neurotoxin,..