Journal article
Zinc in the physiology and pathology of the CNS
SL Sensi, P Paoletti, AI Bush, I Sekler
Nature Reviews Neuroscience | NATURE PUBLISHING GROUP | Published : 2009
DOI: 10.1038/nrn2734
Abstract
The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology. The recent development of powerful tools, including zinc-sensitive fluorescent probes, selective chelators and genetically modified animal models, has brought a deeper understanding of the roles of this cation as a crucial intra-and intercellular signalling ion of the CNS, and hence of the neurophysiological importance of zinc-dependent pathways and the injurious effects of zinc dyshomeostasis. The development of some innovative therapeutic strategies is aimed at controlling and preventing the damaging effects of this cation in neurological conditions such as stroke and Alzheimer's disease. © 2009 Macm..
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Awarded by Australian Research Council
Funding Acknowledgements
We are in debt to M. Hershfinkel, A. Vergnano, V. Frazzini, and M. E. Oberschlake for help with the preparation of the manuscript. S. L. S. is supported by funds from the Italian Department of Education (FIRB 2003; PRIN 2006). P. P. is supported by Institut National de la Sante et de la Recherche Medicale (INSERM), France, Agence Nationale de la Recherche (ANR), France, and Fondation pour la Recherche Medicale (FRM; Equipe FRM grant). A. I. B. is supported with funds from the National Health and Medical Research Council of Australia, and The Australian Research Council. Work described in this review was partially supported by I.S.