Journal article
A topographic study of the evolution of the MR DWI/PWI mismatch pattern and its clinical impact: A study by the EPITHET and DEFUSE investigators
T Ogata, Y Nagakane, S Christensen, H Ma, BCV Campbell, L Churilov, JM Olivot, PM Desmond, GW Albers, SM Davis, GA Donnan
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2011
Abstract
Background And Purpose- The ischemic penumbra may be classical, with complete annular configuration around the infarct core, or nonclassical with a more fragmented pattern. We tested the hypotheses that these penumbral patterns may: be associated with specific predictive factors, influence infarct growth and clinical outcome, and influence the effect of tissue plasminogen activator (t-PA). Methods- Using the EPITHET/DEFUSE data set, in which patients received alteplase or placebo 3 to 6 hours poststroke, perfusion-weighted imaging and diffusion-weighted imaging images were analyzed. These mismatch patterns were defined as "classical" or "nonclassical." Multivariate analysis was used to ident..
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Funding Acknowledgements
[ "This research was supported by the Victorian Government's Operational Infrastructure Support Program.", "G. A. D. is a member of the Boehringer Ingelheim, PAION, Servier, and Sanofi-Aventis advisory boards, has accepted honoraria or consultancy payments from, and has had the costs of participating in scientific meetings reimbursed by, Boehringer Ingelheim, Sanofi-Aventis, and Servier. G. A. D. has received grants from Sanofi-Aventis, and grants and consultancy payments from Boehringer Ingelheim. S. M. D. is a member of the PAION, Servier, and Novo Nordisk advisory boards, and has received honoraria for lectures from Novo Nordisk, Sanofi-Aventis, Pfizer, and Boehringer Ingelheim. G. W. A. is a consultant for Genentech and a member of the Steering Committee for Lundbeck." ]