Journal article
Prenatal administration of Lactobacillus rhamnosus has no effect on the diversity of the early infant gut microbiota
IH Ismail, F Oppedisano, SJ Joseph, RJ Boyle, RM Robins-Browne, MLK Tang
Pediatric Allergy and Immunology | Published : 2012
Abstract
We have recently shown that maternal administration of Lactobacillus rhamnosus GG (LGG) during late pregnancy can have beneficial effects on the early development of infant gut microbiota, promoting a bifidobacteria profile similar to that of a healthy breastfed infant. It is uncertain, however, whether such probiotic supplementation could influence the diversity of infant gut microbiota. We investigated the effect of pre-natal LGG on gut microbial diversity in the early post-natal period. Day-7 faecal samples were collected from 98 infants at high risk of allergic disease, whose mothers participated in a pre-natal probiotic eczema prevention study. Faecal microbial diversity was assessed by..
View full abstractGrants
Funding Acknowledgements
The studies were funded by grants from the Jack Brockhoff Foundation, the Murdoch Children's Research Institute, the Ilhan Food Allergy Foundation, and the Victorian Government's Operational Infrastructure Support Program. Intan Hakimah Ismail was supported by a scholarship from the Ministry of Higher Education, Malaysia and Universiti Putra Malaysia. Robert Boyle was supported by a University of Melbourne Baillieu Scholarship, a Murdoch Children's Research Institute Postgraduate Scholarship and a National Institute for Health Research Comprehensive Biomedical Research Centre. LGG and placebo capsules were manufactured and supplied by Dicofarm ltd (Roma, Italy).