Book Chapter

The Essential Role of Evasion from Cell Death in Cancer

Gemma L Kelly, Andreas Strasser

ADVANCES IN CANCER RESEARCH, VOL 111 | Advances in Cancer Research | ELSEVIER ACADEMIC PRESS INC | Published : 2011

Abstract

The link between evasion of apoptosis and the development of cellular hyperplasia and ultimately cancer is implicitly clear if one considers how many cells are produced each day and, hence, how many cells must die to make room for the new ones (reviewed in Raff, 1996). Furthermore, cells are frequently experiencing noxious stimuli that can cause lesions in their DNA and faults in DNA replication can occur during cellular proliferation. Such DNA damage needs to be repaired efficiently or cells with irreparable damage must be killed to prevent subsequent division of aberrant cells that may fuel tumorigenesis (reviewed in Weinberg, 2007). The detection of genetic lesions in human cancers that a..

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